Flow Cytometry in Double and Triple Hit Lymphomas
نویسندگان
چکیده
منابع مشابه
Double-hit and Triple-hit Lymphomas: New Perspectives for Their Classification
In 2016, an update on the classification of lymphoid neoplasm was published, and one of the modifications made focussed on B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt’s lymphoma, a term which has now been abandoned. This represented a very difficult disease in the diagnostic routine of pathologists. The new proposed term is high-...
متن کاملDouble-hit B-cell lymphomas.
In many B-cell lymphomas, chromosomal translocations are biologic and diagnostic hallmarks of disease. An intriguing subset is formed by the so-called double- hit (DH) lymphomas that are defined by a chromosomal breakpoint affecting the MYC/8q24 locus in combination with another recurrent breakpoint, mainly a t(14;18)(q32;q21) involving BCL2. Recently, these lymphomas have received increased at...
متن کاملDoes the proliferation fraction help identify mature B cell lymphomas with double- and triple-hit translocations?
AIMS The entity 'B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma (DLBCL) and Burkitt lymphoma (BL)' refers to B cell neoplasms that share overlapping characteristics of BL and DLBCL. A subset of these 'grey-zone lymphomas' possesses C-MYC and IGH translocations but, in addition, contains additional rearrangements of BCL2 and/or BCL6 genes. The a...
متن کاملClinical Significance of “Double-hit” and “Double-protein” expression in Primary Gastric B-cell Lymphomas
BACKGROUND AND AIMS Primary gastric B-cell lymphoma is the second most common malignancy of the stomach. There are many controversial issues about its diagnosis, treatment and clinical management. "Double-hit" and "double-protein" involving gene rearrangement and protein expression of c-Myc and bcl2/bcl6 are the most used terms to describe DLBCL poor prognostic factors in recent years. However,...
متن کاملPrognostic importance of DNA flow cytometry in non-Hodgkin's lymphomas.
Eighty one cases of non-Hodgkin's lymphoma were examined by DNA flow cytometry, using fixed embedded histological tissue. The frequency of detection of DNA aneuploidy and the values for S phase fractions depended on the histological subtype and grade of lymphoma. Twenty two of the patients with low grade centroblastic/centrocytic non-Hodgkin's lymphoma had repeat biopsies. Eleven of these patie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cytometry Part B: Clinical Cytometry
سال: 2019
ISSN: 1552-4949,1552-4957
DOI: 10.1002/cyto.b.21788